What Is Rejuran Commonly Used in Korean Dermatology Clinics? How to Tell Apart the Features of Its Different Lines?

Anyone who has visited a Korean dermatology clinic has probably heard of Rejuran. It is one of the most frequently used skin booster treatments in South Korea.
But what exactly is Rejuran? How is it different from regular skin boosters? And how do you choose between its various product lines? Let’s break it down systematically today.
What Is Rejuran?
The core active ingredient of Rejuran is Polynucleotide (PN), DNA fragments extracted from salmon sperm.
Its working principle: Polynucleotide is injected into the skin. These DNA fragments stimulate the skin’s self-repair mechanism, boosting fibroblast activity, accelerating collagen regeneration, and improving skin elasticity and texture.
Essentially, Rejuran is not a hydration-focused skin booster. Instead, it is a regenerative repair skin booster. This is its most fundamental difference from conventional hyaluronic acid skin boosters.
Rejuran vs Other Skin Boosters
**Comparison Item**: Rejuran | Regular Hyaluronic Acid Skin Booster
Core Ingredient: Polynucleotide (PN) | Hyaluronic Acid
Main Benefits: Regeneration & repair, anti-inflammation, skin thickening | Hydration and moisture retention
Onset of Results: Gradually visible in 2–4 weeks | Instant hydration
Duration of Effects: 6–12 months | 1–3 months
Suitable Skin Types: Sensitive, thin, inflamed skin | Dry and dehydrated skin

Different Rejuran Product Lines
Rejuran offers multiple lines with distinct formulations and targeted benefits:
Rejuran Black
The iconic original Rejuran product, also known as Rejuran Baby Skin Injection.
Ingredients: High-concentration PN
Benefits: Full skin repair, anti-aging, strengthening the skin barrier
Best for: People with thin, sensitive skin and anti-aging needs
Injection method: Typically manual injection, targeted on problem areas
Rejuran HB
An upgraded version of Rejuran Black with added numbing agent.
Ingredients: PN + anesthetic component
Benefits: Same effects as Rejuran Black, with a more comfortable injection experience
Best for: Those with low pain tolerance
Note: Effect longevity is similar to Rejuran Black
Rejuran Classic
Lower PN concentration with a more budget-friendly price tag.
Ingredients: Standard-strength PN
Benefits: Basic skin repair and skin rejuvenation
Best for: First-time Rejuran users or clients on a tighter budget
Rejuran I
Rejuran specially formulated for the eye area.
Ingredients: Custom PN formula for periorbital skin
Benefits: Improve fine lines, dark circles and thin skin around the eyes
Features: Injected at a shallower depth, tailored to the thinness of periorbital skin
Who Is Suitable for Rejuran?
Rejuran’s standout strengths are skin thickening and anti-inflammatory repair. It is especially ideal for:
People with thin and easily sensitive skin
Those with broken capillaries or rosacea-prone skin
Individuals with damaged skin barrier and recurring acne
Patients wanting faster recovery after laser treatments
People with aging skin who wish to thicken the dermis
If your primary goal is simple hydration, conventional hyaluronic acid skin boosters may be a more straightforward option. Rejuran works better for those seeking skin repair and anti-aging results.
Limitations of Rejuran
Rejuran is not a one-size-fits-all miracle treatment:
It delivers less immediate hydration compared to hyaluronic acid skin boosters
Its effect on deep wrinkles is limited
It comes with a relatively high price point
Multiple sessions are required for noticeable improvements (usually 3 sessions make up one full course)
If you want to learn more about common treatments at Korean dermatology clinics and their features, you can research on aesthetic education platforms such as Romantic Gangnam before your trip to South Korea.